Endocrine Abstracts

Acute lymphoblastic leukaemia is the commonest malignancy to occur during childhood. Treatment protocols included prophylactic cranial radiotherapy at doses of 18-24Gy. Radiation to the hypothalamic-pituitary axis causes hypopituitarism, the severity of which depends upon the dose and time from treatment. Adults who received 24Gy up to 25 years ago have been shown to be GH deficient, those who received 18Gy were not. Other pituitary function was reported be normal. The purpose...